CLINICAL OPERATIONS MANAGER at Desmond Tutu Health Foundation

Job Description:

Latest job information from Desmond Tutu Health Foundation for the position of CLINICAL OPERATIONS MANAGER. If the CLINICAL OPERATIONS MANAGER vacancy in South Africa matches your qualifications, please submit your latest application or CV directly through the updated Jobkos job portal.

Please note that applying for a job may not always be easy, as new candidates must meet certain qualifications and requirements set by the company. We hope the career opportunity at Desmond Tutu Health Foundation for the position of CLINICAL OPERATIONS MANAGER below matches your qualifications.

CLINICAL OPERATIONS MANAGER

PERMANENT

PHILIPPI VILLAGE

The Desmond Tutu Health Foundation (DTHF) is a registered non-profit organization focused on the pursuit of excellence in research, treatment, training and prevention of HIV and related infections in Southern Africa. 

We have fantastic job opportunities across our businesses for talented people wanting to realize their full potential. Could that be you? If so, we invite you to explore the possibility of joining us to play your part in Desmond Tutu Health Foundations’ exciting future.

The main purpose of the Clinical Operations Manager is to oversee day-to-day operations for a large-scale HIV prevention project, supporting the Site Lead and managing the Project Manager. This role ensures high-quality service delivery, compliance with protocols and smooth site operations. Key responsibilities include managing clinical research, financial activities and the rollout of PrEP and integrated HIV/SRH services for adolescents across multiple sites. The manager acts as a bridge between the Site Lead and Project Manager, ensuring seamless execution, monitoring timelines and addressing challenges proactively.

• Master’s degree in public health, Health Sciences, Social Sciences, or a related field OR
  Master of Business Administration (MBA) with a focus on health systems, project operations, or non-profit management.
• Minimum 5 years of experience in clinical research, HIV prevention programmes or implementation science.
• Working knowledge of GCP, ethics processes, and clinical trial operations.
• Experience working in NGOs or donor-funded programmes.
• Use of Project Management software to coordinate and track project deliverables and analyze performance metrics
• Experience supporting or supervising large teams.
• Experience with PrEP, SRH services, adolescent/youth programmes.
• Knowledge of Project budget and financial literacy
• Familiarity with regulatory submissions (HREC, SAHPRA, NHRD).
• Strong organizational skills and ability to handle multiple concurrent deadlines
• Strong administration, coordination, and communication skills. 

Advantageous:

• Additional training in clinical research operations, implementation science, quality management, or health systems strengthening

Responsibilities:

Clinical Operations & Site Support

• Coordinate daily clinical and non-clinical operations at site.
• Support Site Lead with project implementation, workflow optimization, scheduling and staffing needs.
• Manage logistics for project activities, including supplies, equipment, bookings, and site readiness.
• Ensure timely completion of site-level study documentation, forms, CRFs, logs, and filing.
• Track and follow up on ethics submissions, amendments, reports, and approvals as delegated.
• Support operational setup tasks such as lab processes, BARC setup, pharmacy arrangements, NHRD/CoCT submissions.
• Ensure project deliverables are on track
• Lead the development of the quarterly, semi-annual and annual progress narratives
• Ensure compliance to the budgets and implementation standards
• Routinely review performance data, generate insights, and lead course correction or acceleration plans.
• Develop a project risk matrix  

Clinical Research Processes & Quality

• Ensure adherence to study protocols, GCP, SOPs and regulatory requirements.
• Support development or revision of SOPs under guidance of Site Lead.
• Monitor data entry, documentation quality, and follow-up on data queries with data management teams.
• Coordinate with clinical staff to ensure accurate visit documentation, safety reporting and specimen workflows.
• Assist with preparation of accreditation reports, monitoring visits, audits and quality checks.
• Convene progress meetings with implementation and technical teams on an ongoing basis
• Routinely review performance data, generate insights, and lead course correction or acceleration plans.
• Support development of annual work plans, timelines, staff structures, and resource requirements. 

Stakeholder & Team Coordination

• Act as a key point of communication between Site Lead, Project Manager, and multidisciplinary teams.
• Support management of youth engagement, community partners, and operational stakeholders.
• Facilitate communication around funder visits, external partner requests and site-level presentations.
• Maintain productive working relationships with NDoH, provincial/district partners, partner NGOs, community structures, and referral networks.
• Coordinate communications and alignment between internal stakeholders (sites, IS teams, data, clinical leads, HR, Operations).
• Document and disseminate best practices, learnings, and innovations emerging from project implementation 

Finance & Project Support

• Support preparation of reports for ethics committees, funders, and internal leadership.
• Assist with updating project trackers, procurement lists, training logs, and reporting templates.
• Co-ordinate drafting of technical inputs (abstracts, operational reports, admin sections of proposals) when required.
• Track project expenditure against deliverables and adapt spending as necessary
• Regularly scrutinize financial reports and liaise with GFO for input
• Approval of financial expenditure
• Oversight of procurement and compliance with procurement policy 

Team Support & Supervisory Functions

• Provide day-to-day support to clinical and operational staff to ensure smooth functioning.
• Support onboarding, training scheduling, and competency tracking.
• Promote a positive, accountable, and solution-driven team environment.
• Manage staffing structures required for implementation (clinical, community, IS support, data staff where relevant).
• Conduct bi-annual performance reviews and support professional development.
• Oversee recruitment, onboarding, and training processes.
• Identify performance issues and intervene promptly with coaching or corrective actions.
• Build a high-performing, collaborative, and learning-oriented team culture.

Values fit:  Passion Innovation Progress Integrity Respect Excellence

Submit a detailed cover letter, updated CV with certified copy of highest qualification and details of two (2) current contactable referees by closing 24 December 2025. Incomplete applications will not be considered.

If you are a foreign national applying for this position, please attach a copy of your work permit to your application.

Only short-listed candidates will be contacted.

If you have not heard from us within four weeks after the closing date, please consider your application as unsuccessful.

We are committed to equity in our employment practices. It is our intention to appoint individuals with the aim of meeting our equity objectives. We reserve the right not to appoint if no suitable candidates are identified.

I understand and accept that by applying for this position, I authorized DTHF to process my personal information in accordance with its internal operational requirements.

I further understand that the personal information I disclose to DTHF will be processed in accordance with the requirements set out in the Protection of Personal Information Act and may include the transferring thereof to third parties for the purposes of verification.

This job may be removed before it expires.

Desmond Tutu Health Foundation is a child-friendly organization committed to the protection of children.

For more information about the organization please visit our website.

Job Info:

• Company: Desmond Tutu Health Foundation
• Position: CLINICAL OPERATIONS MANAGER
• Work Location: South Africa
• Country: ZA

How to Submit an Application:

After reading and understanding the criteria and minimum qualification requirements explained in the job information CLINICAL OPERATIONS MANAGER at the office South Africa above, immediately complete the job application files such as a job application letter, CV, photocopy of diploma, transcript, and other supplements as explained above. Submit via the Next Page link below.